COQ4

Across TCGA cell cohorts, COQ4 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COQ4-associated genes across cancer lineages are PRSS54 and LHCGR. Each is linked with COQ4 in more than 1 cancer types. Because this analysis shows association rather than direction, both COQ4-to-partner and partner-to-COQ4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS54 grouped by COQ4-low versus COQ4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COQ4→partner) and Y-score (partner→COQ4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRSS54 →	+0.053	+4.930	<.001	.001	3	1
LARGE_INTESTINE	LHCGR →	+0.050	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

PRSS54 by COQ4 expression — LARGE_INTESTINE

Explore this box plot interactively →