COQ4

Across TCGA cell cohorts, COQ4 mutation is significantly associated with the mutation status of many other genes, with 1,946 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible COQ4-associated genes across cancer lineages are ZKSCAN5, ALAS1, and GNA11. Each is linked with COQ4 in more than 2 cancer types. Because this analysis shows association rather than direction, both COQ4-to-partner and partner-to-COQ4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZKSCAN5 grouped by COQ4-low versus COQ4-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COQ4→partner) and Y-score (partner→COQ4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZKSCAN5 →	+5.832	+5.169	<.001	<.001	1	3
BLOOD_Leukemia	ALAS1 →	+4.479	+5.635	<.001	<.001	1	3
BLOOD_Leukemia	GNA11 →	+4.309	+4.560	.007	.007	1	3
BLOOD_Lymphoma	POFUT1 →	+5.247	+4.429	.005	.005	1	3
BLOOD_Lymphoma	APEH →	+4.247	+4.554	.001	.001	1	3
BLOOD_Lymphoma	ERBB3 →	+2.832	+3.601	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,946 associations by consensus.

ZKSCAN5 by COQ4 expression — BLOOD_Lymphoma

Explore this box plot interactively →