COQ3

Across TCGA patient cohorts, COQ3 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COQ3-associated genes across cancer lineages are MEK1, PCNA, and VHL. Each is linked with COQ3 in more than 1 cancer types. Because this analysis shows association rather than direction, both COQ3-to-partner and partner-to-COQ3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by COQ3-low versus COQ3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COQ3→partner) and Y-score (partner→COQ3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.388	+3.584	.028	.002	3	1
UCEC	PCNA →	+0.293	+2.999	.005	.035	3	1
UCEC	VHL →	-1.026	-3.321	.001	.010	3	1
UCEC	ASNS →	+0.652	+3.169	<.001	.019	3	1
UCEC	Caspase-8 →	-0.241	-3.321	.047	.010	3	1
UCEC	p62 Lck ligand →	+0.404	+3.584	.010	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MEK1 by COQ3 expression — UCEC

Explore this box plot interactively →