COQ3

Across TCGA pan-cancer cohorts, COQ3 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated COQ3 data layer compared with 1 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher COQ3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated COQ3 expression acts as an unfavorable survival marker, although some lineages such as READ and THCA show a favorable association.

KIRC, LIHC, and READ are the cancer types where COQ3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	III,IV	0.596	0.895	.002	72	view →
LIHC	OS	Tertile	All	0.682	0.845	<.001	64	view →
READ	DFS	Quartile	All	0.833	0.291	.003	42	view →
ESCA	OS	Median	All	0.543	0.775	<.001	37	view →
COAD	OS	Tertile	IV	0.179	0.727	.001	27	view →
HNSC	DFS	Median	III,IV	0.501	0.629	.004	27	view →
THCA	OS	Median	II,III,IV	1.000	0.810	.006	23	view →
BRCA	OS	Median	All	0.949	0.974	.004	22	view →
LUAD	OS	Tertile	III,IV	0.528	0.773	.008	20	view →
TGCT	DFS	Tertile	All	0.686	0.931	.001	18	view →
MESO	OS	Median	All	0.422	0.658	.001	15	view →
KICH	DFS	Tertile	All	0.623	0.949	.008	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

COQ3–KIRC (DFS)

Open the KIRC breakdown →