COQ2

Across TCGA cell cohorts, COQ2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible COQ2-associated genes across cancer lineages are SH3GL2, SYT10, and SLC22A6. Each is linked with COQ2 in more than 1 cancer types. Because this analysis shows association rather than direction, both COQ2-to-partner and partner-to-COQ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL2 grouped by COQ2-low versus COQ2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COQ2→partner) and Y-score (partner→COQ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+1.233	+3.474	.002	.003	3	1
BLOOD_Lymphoma	SYT10 →	+0.023	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	SLC22A6 →	+0.009	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	FAM237A →	+0.019	+4.643	<.001	.005	3	1
LARGE_INTESTINE	OR2W3 →	+0.703	+3.355	.008	.007	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SH3GL2 by COQ2 expression — LARGE_INTESTINE

Explore this box plot interactively →