COQ10B

Across TCGA pan-cancer cohorts, COQ10B mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated COQ10B data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher COQ10B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COQ10B expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LUAD, HNSC, and PDAC are the cancer types where COQ10B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.189	0.787	<.001	43	view →
HNSC	DFS	Median	All	0.964	0.428	.049	12	view →
PDAC	DFS	Median	II,III,IV	0.253	0.455	.013	5	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

COQ10B–LUAD (DFS)

Open the LUAD breakdown →