COQ10B

Across TCGA pan-cancer cohorts, COQ10B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of COQ10B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where COQ10B RNA is repressed in tumor relative to normal tissue. In most cancer types COQ10B is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, HNSC, and LIHC are the cancer types where COQ10B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COQ10B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.087	<.001	10	view →
HNSC	Male	III,IV	+0.813	<.001	10	view →
LIHC	Male	III,IV	+0.553	<.001	6	view →
BLCA	All	All	−0.373	.012	6	view →
KIRC	Male	All	−0.238	.002	6	view →
COAD	All	All	−0.332	.007	4	view →
BRCA	All	All	+0.208	.001	4	view →
ESCA	All	All	+0.728	.001	3	view →
PAAD	All	All	+0.557	.043	2	view →
KIRP	Female	II,III,IV	+0.468	.012	2	view →
PRAD	All	All	−0.200	.040	2	view →
CHOL	All	All	+0.711	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

COQ10B–KICH

Open the KICH breakdown →