COQ10B

Across TCGA patient cohorts, COQ10B mutation is significantly associated with the RNA expression of many other genes, with 1,031 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COQ10B-associated genes across cancer lineages are OR6K6, COX6CP7, and LSP1P1. Each is linked with COQ10B in more than 1 cancer types. Because this analysis shows association rather than direction, both COQ10B-to-partner and partner-to-COQ10B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6K6 grouped by COQ10B-low versus COQ10B-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COQ10B→partner) and Y-score (partner→COQ10B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR6K6 →	+0.044	+6.018	<.001	.002	3	2
READ	COX6CP7 →	+0.260	+5.421	<.001	.005	3	2
UCEC	LSP1P1 →	+0.231	+2.021	.006	.008	3	2
UCEC	TRAJ12 →	+0.718	+2.581	<.001	<.001	3	2
UCEC	RNU6-229P →	+0.262	+2.863	<.001	.001	3	2
BLCA	LINC01248 →	+0.208	+5.788	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,031 associations by consensus.

OR6K6 by COQ10B expression — BLCA

Explore this box plot interactively →