COQ10B

Across TCGA patient cohorts, COQ10B mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COQ10B-associated genes across cancer lineages are EGFR_pY1068, JNK2, and p70-S6K_pT389. Each is linked with COQ10B in more than 1 cancer types. Because this analysis shows association rather than direction, both COQ10B-to-partner and partner-to-COQ10B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by COQ10B-low versus COQ10B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COQ10B→partner) and Y-score (partner→COQ10B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.267	-2.459	.014	.019	3	1
UCEC	JNK2 →	+0.235	+2.834	.006	.034	3	1
UCEC	p70-S6K_pT389 →	-0.205	-2.115	.013	.019	3	1
UCEC	Rad50 →	-0.246	-2.115	.020	.019	3	1
UCEC	Annexin-1 →	+0.571	+2.189	.013	.034	3	1
UCEC	Shc_pY317 →	-0.198	-3.906	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

EGFR_pY1068 by COQ10B expression — UCEC

Explore this box plot interactively →