COQ10B

Across TCGA cell cohorts, COQ10B mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COQ10B-associated genes across cancer lineages are CD40LG, NXPH2, and FCN2. Each is linked with COQ10B in more than 1 cancer types. Because this analysis shows association rather than direction, both COQ10B-to-partner and partner-to-COQ10B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD40LG grouped by COQ10B-low versus COQ10B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COQ10B→partner) and Y-score (partner→COQ10B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CD40LG →	+0.073	+4.467	<.001	.004	3	1
LARGE_INTESTINE	NXPH2 →	+0.045	+4.273	.004	.006	3	1
LARGE_INTESTINE	FCN2 →	+0.039	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CCDC42 →	+0.049	+4.095	<.001	.009	3	1
LARGE_INTESTINE	EMCN →	+0.024	+4.684	<.001	.002	3	1
LARGE_INTESTINE	MAGEB10 →	+0.101	+4.930	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

CD40LG by COQ10B expression — LARGE_INTESTINE

Explore this box plot interactively →