COPS8P3

Across TCGA pan-cancer cohorts, COPS8P3 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated COPS8P3 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher COPS8P3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated COPS8P3 expression acts as an unfavorable survival marker, although some lineages such as OV and UVM show a favorable association.

SKCM, OV, and BLCA are the cancer types where COPS8P3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	IV	0.215	0.867	<.001	75	view →
OV	DFS	Tertile	All	0.212	0.144	.020	60	view →
BLCA	OS	Tertile	III,IV	0.120	0.588	<.001	57	view →
UVM	DFS	Quartile	All	0.699	0.331	.004	21	view →
PAAD	OS	Tertile	All	0.671	0.351	.024	12	view →
KIRC	DFS	Tertile	All	0.949	0.860	.021	12	view →
ACC	OS	Tertile	II,III,IV	0.214	0.790	.012	9	view →
LIHC	OS	Tertile	III,IV	0.266	0.594	.013	9	view →
STAD	DFS	Tertile	All	0.310	0.552	.045	6	view →
LAML	DFS	Quartile	All	0.713	0.475	.035	6	view →
UCEC	DFS	Tertile	All	0.837	0.902	.048	6	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

COPS8P3–SKCM (OS)

Open the SKCM breakdown →