Across TCGA pan-cancer cohorts, COPS8P1 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of COPS8P1’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where COPS8P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types COPS8P1 is over-expressed in tumor.
LUSC are the cancer types where COPS8P1 tumor–normal differential expression is most reproducible.