COPS7A

Across TCGA patient cohorts, COPS7A mutation is significantly associated with the RNA expression of many other genes, with 1,116 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COPS7A-associated genes across cancer lineages are MIR4286, RNU6-172P, and TRAJ57. Each is linked with COPS7A in more than 1 cancer types. Because this analysis shows association rather than direction, both COPS7A-to-partner and partner-to-COPS7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4286 grouped by COPS7A-low versus COPS7A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS7A→partner) and Y-score (partner→COPS7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR4286 →	+0.253	+3.717	.002	.005	3	2
COAD	RNU6-172P →	+0.929	+4.790	<.001	.006	3	2
UCEC	TRAJ57 →	+0.358	+1.997	.001	.007	3	2
LUSC	CKS1BP5 →	+0.247	+6.291	<.001	<.001	3	2
SKCM	MIR301A →	+0.314	+4.159	<.001	.002	3	2
UCEC	IGKV1OR2-6 →	+0.640	+2.810	.006	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,116 associations by consensus.

MIR4286 by COPS7A expression — SKCM

Explore this box plot interactively →