COPS3

Across TCGA patient cohorts, COPS3 protein abundance is significantly associated with the protein abundance of many other proteins, with 9,305 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible COPS3-associated proteins across cancer lineages are COPS4, GPS1, and COPS2. Each is linked with COPS3 in more than 8 cancer types. Because this analysis shows association rather than direction, both COPS3-to-partner and partner-to-COPS3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COPS3 versus COPS4 in OV, with a Pearson correlation of 0.78.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS3→partner) and Y-score (partner→COPS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	COPS4 →	+0.282	+0.267	<.001	<.001	3	9
OV	GPS1 →	+0.213	+0.232	<.001	<.001	3	9
BRCA	COPS2 →	+0.269	+0.234	<.001	<.001	3	9
BRCA	COPS5 →	+0.229	+0.208	<.001	<.001	3	8
BRCA	COPS6 →	+0.285	+0.223	<.001	<.001	3	8
BRCA	COPS7A →	+0.379	+0.185	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,305 associations by consensus.

COPS3 vs COPS4 — OV

Explore this scatter interactively →