COPE

Across TCGA patient cohorts, COPE RNA expression is significantly associated with the protein abundance of many other proteins, with 7,700 significant associations in total. COAD shows the largest number of these associations.

The most reproducible COPE-associated proteins across cancer lineages are SLC35E1, FKBP8, and CHAF1B_S410. Each is linked with COPE in more than 3 cancer types. Because this analysis shows association rather than direction, both COPE-to-partner and partner-to-COPE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COPE versus SLC35E1 in PDAC, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (COPE→partner) and Y-score (partner→COPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SLC35E1 →	+0.379	+0.185	<.001	<.001	3	4
LSCC	FKBP8 →	+0.354	+0.446	<.001	<.001	3	4
LSCC	CHAF1B_S410 →	+0.938	+0.382	<.001	<.001	3	4
LSCC	DNMT1_S714 →	+0.649	+0.411	.002	<.001	3	4
COAD	NUDC →	+0.350	+0.441	.004	.001	3	3
GBM	STX8 →	-0.216	-0.239	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,700 associations by consensus.

COPE vs SLC35E1 — PDAC

Explore this scatter interactively →