COPE

Across TCGA pan-cancer cohorts, COPE RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of COPE’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where COPE RNA is more highly expressed in tumor relative to normal tissue. In most cancer types COPE is over-expressed in tumor.

KIRC, COAD, and KIRP are the cancer types where COPE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COPE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	+0.671	<.001	12	view →
COAD	All	III,IV	+0.673	<.001	11	view →
KIRP	Male	III,IV	+0.629	<.001	11	view →
LIHC	Female	II,III,IV	+1.400	<.001	9	view →
BLCA	Male	All	+0.837	<.001	8	view →
HNSC	Male	III,IV	+0.558	<.001	8	view →
UCEC	All	III,IV	+1.057	<.001	6	view →
BRCA	All	III,IV	+0.857	<.001	6	view →
LUSC	All	II,III,IV	+0.478	<.001	6	view →
LUAD	Female	II,III,IV	+0.377	.006	4	view →
CHOL	All	All	+1.448	<.001	3	view →
STAD	All	All	+0.436	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

COPE–KIRC

Open the KIRC breakdown →