COPE

Across TCGA patient cohorts, COPE protein abundance is significantly associated with the RNA expression of many other genes, with 15,232 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible COPE-associated genes across cancer lineages are KDELR3, SRSF3, and MDN1. Each is linked with COPE in more than 5 cancer types. Because this analysis shows association rather than direction, both COPE-to-partner and partner-to-COPE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COPE versus KDELR3 in OV, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPE→partner) and Y-score (partner→COPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	KDELR3 →	+0.939	+0.208	<.001	<.001	3	6
HNSC	SRSF3 →	-0.439	-0.182	.007	.002	3	5
BRCA	MDN1 →	-0.433	-0.183	<.001	<.001	3	5
LSCC	TSEN2 →	-0.644	-0.252	<.001	<.001	3	5
CCRCC	RTTN →	-0.406	-0.134	<.001	.004	3	5
UCEC	SSR4 →	+1.060	+0.226	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,232 associations by consensus.

COPE vs KDELR3 — OV

Explore this scatter interactively →