COPE

Across TCGA patient cohorts, COPE mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. COAD shows the largest number of these associations.

The most reproducible COPE-associated genes across cancer lineages are Macrophages, Astrocytes, and Neutrophils. Each is linked with COPE in more than 1 cancer types. Because this analysis shows association rather than direction, both COPE-to-partner and partner-to-COPE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macrophages grouped by COPE-low versus COPE-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPE→partner) and Y-score (partner→COPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Macrophages →	+0.040	+3.025	<.001	.009	3	2
COAD	Astrocytes →	+0.079	+2.522	<.001	.026	3	1
COAD	Neutrophils →	+0.016	+2.394	<.001	.033	3	1
UCEC	Keratinocytes →	-0.018	-3.041	.017	.021	1	1
UCEC	Sebocytes →	-0.037	-3.148	.006	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Macrophages by COPE expression — COAD

Explore this box plot interactively →