COPE

Across TCGA cell cohorts, COPE RNA expression is significantly associated with the go_rna of many other GO terms, with 2,713 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible COPE-associated GO terms across cancer lineages are Regulation of glycolytic process through fructose-6-phosphate, Negative regulation of glycolytic process through fructose-6-phosphate, and Negative regulation of protein localization to chromatin. Each is linked with COPE in more than 14 cancer types. Because this analysis shows association rather than direction, both COPE-to-partner and partner-to-COPE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of glycolytic process through fructose-6-phosphate grouped by COPE-low versus COPE-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COPE→partner) and Y-score (partner→COPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of glycolytic process through fructose-6-phosphate →	+0.157	+0.995	.004	.001	3	15
LIVER	Negative regulation of glycolytic process through fructose-6-phosphate →	+0.157	+0.995	.004	.001	3	15
UPPER_AERODIGESTIVE_TRACT	Negative regulation of protein localization to chromatin →	+0.114	+0.630	.002	.001	3	10
SKIN	Negative regulation of inflammasome-mediated signaling pathway →	+0.092	+0.502	<.001	<.001	3	8
SOFT_TISSUE	Protein insertion into membrane →	+0.068	+0.472	<.001	.003	3	8
BLOOD_Leukemia	GDP-mannose biosynthetic process →	+0.113	+0.459	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,713 associations by consensus.

Regulation of glycolytic process through fructose-6-phosphate by COPE expression — LIVER

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