COPB1

Across TCGA pan-cancer cohorts, COPB1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated COPB1 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher COPB1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COPB1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

LSCC, UCEC, and PDAC are the cancer types where COPB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.441	0.840	.007	14	view →
UCEC	DFS	Tertile	All	0.948	0.817	.026	12	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
HNSC	DFS	Tertile	III,IV	0.871	0.708	.015	6	view →
GBM	DFS	Quartile	All	0.220	0.413	.019	5	view →
LUAD	OS	Tertile	All	0.482	0.868	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

COPB1–LSCC (DFS)

Open the LSCC breakdown →