COPB1

Across TCGA patient cohorts, COPB1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COPB1-associated genes across cancer lineages are ATM, GAPDH, and ASNS. Each is linked with COPB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both COPB1-to-partner and partner-to-COPB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by COPB1-low versus COPB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPB1→partner) and Y-score (partner→COPB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.462	-2.308	<.001	.005	3	3
COAD	GAPDH →	+0.560	+2.820	.024	.035	3	2
COAD	ASNS →	+0.629	+3.178	.001	.010	3	2
UCEC	eIF4E →	+0.183	+1.473	.004	.006	3	2
UCEC	JNK2 →	+0.179	+1.473	.003	.006	3	2
UCEC	P-Cadherin →	-0.117	-2.222	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

ATM by COPB1 expression — UCEC

Explore this box plot interactively →