COPB1

Across TCGA cell cohorts, COPB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,120 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible COPB1-associated GO terms across cancer lineages are Endoplasmic reticulum to Golgi vesicle-mediated transport, Vesicle cargo loading, and COPII-coated vesicle cargo loading. Each is linked with COPB1 in more than 15 cancer types. Because this analysis shows association rather than direction, both COPB1-to-partner and partner-to-COPB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endoplasmic reticulum to Golgi vesicle-mediated transport grouped by COPB1-low versus COPB1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COPB1→partner) and Y-score (partner→COPB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.083	+0.857	<.001	<.001	3	16
BONE	Vesicle cargo loading →	+0.127	+0.762	<.001	<.001	3	15
STOMACH	COPII-coated vesicle cargo loading →	+0.128	+0.866	<.001	<.001	3	15
BONE	Positive regulation of protein exit from endoplasmic reticulum →	+0.155	+0.957	<.001	<.001	3	15
BONE	Regulation of protein exit from endoplasmic reticulum →	+0.165	+0.904	<.001	.002	3	13
STOMACH	Golgi vesicle transport →	+0.067	+0.650	.002	.004	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,120 associations by consensus.

Endoplasmic reticulum to Golgi vesicle-mediated transport by COPB1 expression — BONE

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