COPB1

Across TCGA cell cohorts, COPB1 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible COPB1-associated genes across cancer lineages are CSH1, GALR1, and CDX4. Each is linked with COPB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COPB1-to-partner and partner-to-COPB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSH1 grouped by COPB1-low versus COPB1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPB1→partner) and Y-score (partner→COPB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CSH1 →	+0.482	+3.791	.002	.007	3	2
SKIN	GALR1 →	+0.972	+5.022	<.001	.002	3	1
LARGE_INTESTINE	CDX4 →	+0.007	+3.217	.001	.006	3	1
LARGE_INTESTINE	VSIG4 →	+0.024	+3.376	<.001	.002	3	1
LARGE_INTESTINE	IQCF1 →	+0.213	+3.443	<.001	.009	3	1
LARGE_INTESTINE	OR2T29 →	+0.010	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

CSH1 by COPB1 expression — OVARY

Explore this box plot interactively →