COMT

Across TCGA pan-cancer cohorts, COMT Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated COMT data layer compared with 30 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher COMT Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated COMT expression acts as an unfavorable survival marker.

STAD and BLCA are the cancer types where COMT Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.098	0.539	.008	12	view →
BLCA	DFS	Median	III,IV	0.211	0.576	.016	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

COMT–STAD (OS)

Open the STAD breakdown →