COMT

Across TCGA patient cohorts, COMT RNA expression is significantly associated with the RNA expression of many other genes, with 18,421 significant associations in total. ACC shows the largest number of these associations.

The most reproducible COMT-associated genes across cancer lineages are LZTR1, TSPO, and TXNRD2. Each is linked with COMT in more than 29 cancer types. Because this analysis shows association rather than direction, both COMT-to-partner and partner-to-COMT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COMT versus LZTR1 in ACC, with a Pearson correlation of 0.44.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMT→partner) and Y-score (partner→COMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	LZTR1 →	+0.900	+1.071	<.001	<.001	3	30
ACC	TSPO →	+1.293	+0.955	<.001	<.001	3	29
ACC	TXNRD2 →	+0.937	+1.039	<.001	<.001	3	29
ACC	LMF2 →	+1.404	+1.181	<.001	<.001	3	29
LAML	ZDHHC8 →	+1.021	+0.772	<.001	<.001	3	29
ACC	MED15 →	+0.718	+0.960	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,421 associations by consensus.

COMT vs LZTR1 — ACC

Explore this scatter interactively →