COMT

Across TCGA patient cohorts, COMT protein abundance is significantly associated with the RNA expression of many other genes, with 10,438 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible COMT-associated genes across cancer lineages are RTCB, BCL2L13, and HPS4. Each is linked with COMT in more than 6 cancer types. Because this analysis shows association rather than direction, both COMT-to-partner and partner-to-COMT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COMT versus RTCB in HNSC, with a Pearson correlation of 0.26.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMT→partner) and Y-score (partner→COMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RTCB →	+0.649	+0.307	.007	.002	3	7
LSCC	BCL2L13 →	+0.535	+0.387	<.001	<.001	3	7
UCEC	HPS4 →	+0.625	+0.340	<.001	<.001	3	5
UCEC	MTMR3 →	+0.509	+0.561	<.001	<.001	3	5
BRCA	TXN2 →	+0.585	+0.594	<.001	<.001	3	5
LSCC	ATP6V1E1 →	+0.399	+0.312	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,438 associations by consensus.

COMT vs RTCB — HNSC

Explore this scatter interactively →