COMT

Across TCGA patient cohorts, COMT mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COMT-associated genes across cancer lineages are CD8+ naive T-cells, aDC, and cDC. Each is linked with COMT in more than 1 cancer types. Because this analysis shows association rather than direction, both COMT-to-partner and partner-to-COMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ naive T-cells grouped by COMT-low versus COMT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMT→partner) and Y-score (partner→COMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD8+ naive T-cells →	+0.057	+2.839	<.001	.034	3	1
UCEC	aDC →	+0.097	+2.815	.023	.036	2	1
UCEC	cDC →	+0.139	+3.000	.003	.037	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CD8+ naive T-cells by COMT expression — UCEC

Explore this box plot interactively →