COMT

Across TCGA cell cohorts, COMT RNA expression is significantly associated with the go_rna of many other GO terms, with 4,759 significant associations in total. BONE shows the largest number of these associations.

The most reproducible COMT-associated GO terms across cancer lineages are Negative regulation of actin filament depolymerization, Symbiont-mediated disruption of host cellular anatomical structure, and Symbiont-mediated disruption of host anatomical structure. Each is linked with COMT in more than 9 cancer types. Because this analysis shows association rather than direction, both COMT-to-partner and partner-to-COMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of actin filament depolymerization grouped by COMT-low versus COMT-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COMT→partner) and Y-score (partner→COMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of actin filament depolymerization →	+0.246	+1.364	<.001	<.001	3	10
BREAST	Symbiont-mediated disruption of host cellular anatomical structure →	+0.124	+1.123	<.001	<.001	3	10
BREAST	Symbiont-mediated disruption of host anatomical structure →	+0.124	+1.123	<.001	<.001	3	10
BONE	Inositol biosynthetic process →	-0.191	-1.039	<.001	<.001	3	10
LIVER	Regulation of Golgi inheritance →	+0.163	+1.911	.006	.002	3	10
BONE	Positive regulation of retrograde protein transport, ER to cytosol →	+0.189	+1.344	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,759 associations by consensus.

Negative regulation of actin filament depolymerization by COMT expression — BONE

Explore this box plot interactively →