COMT

Across TCGA cell cohorts, COMT mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible COMT-associated genes across cancer lineages are TSSK1B and ASB17. Each is linked with COMT in more than 1 cancer types. Because this analysis shows association rather than direction, both COMT-to-partner and partner-to-COMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSSK1B grouped by COMT-low versus COMT-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMT→partner) and Y-score (partner→COMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TSSK1B →	+0.014	+4.874	<.001	.002	3	1
OVARY	ASB17 →	+0.023	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

TSSK1B by COMT expression — BLOOD_Leukemia

Explore this box plot interactively →