COMT

Across TCGA cell cohorts, COMT mutation is significantly associated with the mutation status of many other genes, with 3,071 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible COMT-associated genes across cancer lineages are SLC5A1, CENPT, and FKBP8. Each is linked with COMT in more than 2 cancer types. Because this analysis shows association rather than direction, both COMT-to-partner and partner-to-COMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC5A1 grouped by COMT-low versus COMT-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMT→partner) and Y-score (partner→COMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC5A1 →	+5.285	+5.285	<.001	<.001	1	3
OVARY	CENPT →	+5.415	+5.415	.004	.004	1	3
OVARY	FKBP8 →	+5.415	+5.415	.004	.004	1	3
OVARY	KAT2A →	+5.415	+5.415	.004	.004	1	3
OVARY	PRDM4 →	+5.415	+5.415	.004	.004	1	3
OVARY	WNT6 →	+5.415	+5.415	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,071 associations by consensus.

SLC5A1 by COMT expression — BLOOD_Leukemia

Explore this box plot interactively →