COMMD8

Across TCGA patient cohorts, COMMD8 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COMMD8-associated genes across cancer lineages are eIF4G, BRCA2, and Ku80. Each is linked with COMMD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both COMMD8-to-partner and partner-to-COMMD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by COMMD8-low versus COMMD8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMMD8→partner) and Y-score (partner→COMMD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.463	+3.000	.009	.037	3	1
UCEC	BRCA2 →	-0.160	-2.992	.029	.036	3	1
UCEC	Ku80 →	+0.381	+3.013	.005	.019	2	1
UCEC	Smad3 →	+0.175	+3.000	.045	.037	2	1
UCEC	CD49b →	-0.471	-2.986	.004	.037	2	1
UCEC	C-Raf →	+0.186	+3.000	.024	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

eIF4G by COMMD8 expression — UCEC

Explore this box plot interactively →