COMMD5

Across TCGA patient cohorts, COMMD5 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COMMD5-associated genes across cancer lineages are p62 Lck ligand, 4E-BP1, and JNK2. Each is linked with COMMD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both COMMD5-to-partner and partner-to-COMMD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by COMMD5-low versus COMMD5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMMD5→partner) and Y-score (partner→COMMD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.435	+2.179	.010	.034	3	1
UCEC	4E-BP1 →	+0.445	+2.837	.001	.035	3	1
UCEC	JNK2 →	+0.366	+2.817	<.001	.036	2	1
UCEC	PI3K-p85 →	+0.236	+3.321	.031	.010	2	1
UCEC	BRD4 →	+0.344	+2.177	.014	.035	2	1
UCEC	Di-Ras3 →	-0.233	-3.321	.002	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

p62 Lck ligand by COMMD5 expression — UCEC

Explore this box plot interactively →