COMMD5

Across TCGA pan-cancer cohorts, COMMD5 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated COMMD5 data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher COMMD5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated COMMD5 expression acts as an unfavorable survival marker, although some lineages such as SCLC and CHOL show a favorable association.

UVM, LIHC, and UCS are the cancer types where COMMD5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.426	0.758	<.001	133	view →
LIHC	OS	Tertile	All	0.600	0.771	<.001	78	view →
UCS	OS	Median	IV	0.302	0.817	.002	44	view →
KIRC	DFS	Quartile	All	0.767	0.932	.002	42	view →
HNSC	OS	Median	III,IV	0.554	0.798	.001	34	view →
KICH	OS	Median	III,IV	0.468	1.000	.001	33	view →
MESO	OS	Quartile	All	0.358	0.646	.010	24	view →
SKCM	DFS	Quartile	III,IV	0.533	0.860	.012	19	view →
ACC	OS	Quartile	II,III,IV	0.747	0.970	.013	14	view →
READ	OS	Quartile	IV	0.332	0.913	.010	13	view →
SCLC	OS	Quartile	All	0.481	0.177	.002	12	view →
BRCA	OS	Tertile	All	0.939	0.970	.014	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

COMMD5–UVM (DFS)

Open the UVM breakdown →