COMMD3-BMI1

Across TCGA patient cohorts, COMMD3-BMI1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,911 significant associations in total. THYM shows the largest number of these associations.

The most reproducible COMMD3-BMI1-associated GO terms across cancer lineages are Protein sumoylation, Ribosome-associated ubiquitin-dependent protein catabolic process, and Rescue of stalled ribosome. Each is linked with COMMD3-BMI1 in more than 21 cancer types. Because this analysis shows association rather than direction, both COMMD3-BMI1-to-partner and partner-to-COMMD3-BMI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein sumoylation grouped by COMMD3-BMI1-low versus COMMD3-BMI1-high in UVM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COMMD3-BMI1→partner) and Y-score (partner→COMMD3-BMI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	Protein sumoylation →	+0.048	+0.026	<.001	<.001	3	22
THYM	Ribosome-associated ubiquitin-dependent protein catabolic process →	+0.076	+0.153	<.001	<.001	3	22
UVM	Rescue of stalled ribosome →	+0.060	+0.025	<.001	<.001	3	22
UVM	Membrane fission →	+0.055	+0.029	<.001	<.001	3	22
UCS	Negative regulation of macroautophagy →	+0.047	+0.078	<.001	.002	3	21
DLBC	Negative regulation of protein sumoylation →	+0.066	+0.049	.001	.002	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,911 associations by consensus.

Protein sumoylation by COMMD3-BMI1 expression — UVM

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