COMMD3-BMI1

Across TCGA patient cohorts, COMMD3-BMI1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COMMD3-BMI1-associated genes across cancer lineages are MEK1, Tuberin, and CD49b. Each is linked with COMMD3-BMI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COMMD3-BMI1-to-partner and partner-to-COMMD3-BMI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by COMMD3-BMI1-low versus COMMD3-BMI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMMD3-BMI1→partner) and Y-score (partner→COMMD3-BMI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.521	+3.321	.004	.010	3	1
UCEC	Tuberin →	+0.274	+2.179	.043	.034	3	1
UCEC	CD49b →	-0.345	-2.986	.015	.035	3	1
UCEC	Cyclin-B1 →	+0.587	+3.459	.037	.005	3	1
UCEC	JNK2 →	+0.328	+3.459	.001	.005	1	1
UCEC	p62 Lck ligand →	+0.503	+2.321	.002	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MEK1 by COMMD3-BMI1 expression — UCEC

Explore this box plot interactively →