COMMD3-BMI1

Across TCGA cell cohorts, COMMD3-BMI1 mutation is significantly associated with the mutation status of many other genes, with 237 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COMMD3-BMI1-associated genes across cancer lineages are SLC25A41, CHM, and HDAC10. Each is linked with COMMD3-BMI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COMMD3-BMI1-to-partner and partner-to-COMMD3-BMI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A41 grouped by COMMD3-BMI1-low versus COMMD3-BMI1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMMD3-BMI1→partner) and Y-score (partner→COMMD3-BMI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SLC25A41 →	+4.187	+5.000	.008	.008	1	2
LUNG_NSCLC_LUAD	CHM →	+5.772	+5.772	.002	.002	1	2
LUNG_NSCLC_LUAD	HDAC10 →	+5.772	+5.772	.002	.002	1	1
LUNG_NSCLC_LUAD	LRRC23 →	+5.772	+5.772	.002	.002	1	1
LUNG_NSCLC_LUAD	MTPAP →	+5.772	+5.772	.002	.002	1	1
LUNG_NSCLC_LUAD	PITRM1 →	+4.772	+5.339	.004	.004	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 237 associations by consensus.

SLC25A41 by COMMD3-BMI1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →