COMMD10

Across TCGA pan-cancer cohorts, COMMD10 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated COMMD10 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher COMMD10 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COMMD10 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where COMMD10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.312	0.959	<.001	45	view →
PDAC	DFS	Median	All	0.589	0.325	.002	41	view →
CCRCC	OS	Tertile	All	1.000	0.859	.005	17	view →
UCEC	DFS	Median	II,III,IV	0.425	0.926	.002	12	view →
HNSC	DFS	Median	IV	0.915	0.676	.015	5	view →
LSCC	OS	Tertile	All	0.818	1.000	.049	1	view →
GBM	DFS	Median	All	0.648	0.846	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

COMMD10–LUAD (DFS)

Open the LUAD breakdown →