COMMD1

Across TCGA pan-cancer cohorts, COMMD1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COMMD1 data layer compared with 20 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher COMMD1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated COMMD1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where COMMD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	IV	0.231	0.937	.010	6	view →
HNSC	DFS	Median	IV	0.910	0.709	.027	5	view →
LUAD	DFS	Tertile	All	0.370	0.637	.014	3	view →
CCRCC	OS	Quartile	All	1.000	0.592	.022	2	view →
LSCC	OS	Median	II,III,IV	0.810	1.000	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COMMD1–PDAC (OS)

Open the PDAC breakdown →