COMMD1

Across TCGA pan-cancer cohorts, COMMD1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of COMMD1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where COMMD1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types COMMD1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, KICH, and LIHC are the cancer types where COMMD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COMMD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.464	<.001	11	view →
KICH	Female	II,III,IV	−1.681	<.001	9	view →
LIHC	Male	II,III,IV	+0.645	<.001	8	view →
THCA	All	All	−0.175	.006	6	view →
CHOL	All	All	+0.838	<.001	5	view →
LUSC	All	All	+0.334	<.001	3	view →
KIRP	All	All	−0.229	.019	2	view →
LUAD	All	All	+0.190	.006	2	view →
STAD	Male	All	−0.257	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

COMMD1–KIRC

Open the KIRC breakdown →