COLEC12

Across TCGA pan-cancer cohorts, COLEC12 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COLEC12 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher COLEC12 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COLEC12 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

PDAC, LUAD, and CCRCC are the cancer types where COLEC12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	III,IV	0.170	0.900	.002	32	view →
LUAD	DFS	Median	II,III,IV	0.654	0.981	.008	4	view →
CCRCC	DFS	Tertile	III,IV	0.837	0.227	.013	2	view →
LSCC	OS	Quartile	All	0.713	0.924	.034	2	view →
HNSC	DFS	Tertile	III,IV	0.934	0.697	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COLEC12–PDAC (DFS)

Open the PDAC breakdown →