COLEC12

Across TCGA pan-cancer cohorts, COLEC12 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of COLEC12’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where COLEC12 RNA is repressed in tumor relative to normal tissue. In most cancer types COLEC12 is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

LUAD, COAD, and THCA are the cancer types where COLEC12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COLEC12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−2.005	<.001	11	view →
COAD	Female	II,III,IV	−1.488	<.001	11	view →
THCA	Female	II,III,IV	−1.990	<.001	9	view →
LUSC	Female	II,III,IV	−2.778	<.001	8	view →
UCEC	All	All	−2.070	<.001	8	view →
BLCA	Male	All	−2.667	<.001	7	view →
LIHC	All	II,III,IV	+0.949	<.001	7	view →
BRCA	Female	II,III,IV	−0.616	<.001	6	view →
KIRP	All	II,III,IV	−0.683	.015	4	view →
READ	Female	All	−1.889	.004	2	view →
PRAD	All	All	+1.361	<.001	2	view →
STAD	All	All	−0.822	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

COLEC12–LUAD

Open the LUAD breakdown →