COLEC12

Across TCGA patient cohorts, COLEC12 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COLEC12-associated genes across cancer lineages are Cyclin-B1, Notch1, and TFRC. Each is linked with COLEC12 in more than 2 cancer types. Because this analysis shows association rather than direction, both COLEC12-to-partner and partner-to-COLEC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by COLEC12-low versus COLEC12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COLEC12→partner) and Y-score (partner→COLEC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.658	+2.044	<.001	<.001	3	3
UCEC	Notch1 →	+0.109	+1.165	.006	.029	3	3
UCEC	TFRC →	+0.494	+2.584	<.001	<.001	3	3
LUSC	p21 →	-0.378	-2.000	.006	.028	3	2
STAD	Akt_pS473 →	-0.355	-2.984	.047	.034	3	2
UCEC	Lck →	+0.142	+0.947	.012	.047	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Cyclin-B1 by COLEC12 expression — UCEC

Explore this box plot interactively →