COLEC12

Across TCGA cell cohorts, COLEC12 mutation is significantly associated with the mutation status of many other genes, with 2,641 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COLEC12-associated genes across cancer lineages are ADAMTSL3, EVX2, and B4GALT3. Each is linked with COLEC12 in more than 4 cancer types. Because this analysis shows association rather than direction, both COLEC12-to-partner and partner-to-COLEC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAMTSL3 grouped by COLEC12-low versus COLEC12-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COLEC12→partner) and Y-score (partner→COLEC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ADAMTSL3 →	+3.731	+5.133	<.001	<.001	1	5
LARGE_INTESTINE	EVX2 →	+3.951	+4.321	<.001	<.001	1	4
UPPER_AERODIGESTIVE_TRACT	B4GALT3 →	+5.392	+5.392	.004	.004	1	3
UPPER_AERODIGESTIVE_TRACT	DPP4 →	+4.392	+4.954	.008	.008	1	3
UPPER_AERODIGESTIVE_TRACT	DCLRE1A →	+4.392	+4.954	.008	.008	1	3
LARGE_INTESTINE	CD1E →	+3.799	+3.329	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,641 associations by consensus.

ADAMTSL3 by COLEC12 expression — SKIN

Explore this box plot interactively →