Across TCGA patient cohorts, COLCA2 mutation is significantly associated with the RNA expression of many other genes, with 2,917 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COLCA2-associated genes across cancer lineages are CCL4, CHEK1, and SLC7A11. Each is linked with COLCA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both COLCA2-to-partner and partner-to-COLCA2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COLCA2→partner) and Y-score (partner→COLCA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCL4 →	+0.715	+1.960	.001	<.001	3	2
UCEC	CHEK1 →	+0.552	+3.111	.001	<.001	3	2
UCEC	SLC7A11 →	+0.945	+3.010	<.001	<.001	3	2
UCEC	NCAPD3 →	+0.521	+2.095	.001	.003	3	2
UCEC	GUF1 →	+0.471	+2.544	<.001	<.001	3	2
UCEC	SAR1B →	+0.434	+3.002	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,917 associations by consensus.

Exploration

COLCA2 survival (RNA) · tumor vs normal (RNA) · all COLCA2 data types