Across TCGA pan-cancer cohorts, COLCA2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated COLCA2 data layer compared with 4 for mutation status.
The strongest signal is observed in adrenocortical carcinoma (ACC), where higher COLCA2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated COLCA2 expression acts as an unfavorable survival marker, although some lineages such as ACC and KIRP show a favorable association.
ACC, LIHC, and KIRP are the cancer types where COLCA2 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.