Across TCGA patient cohorts, COLCA2 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COLCA2-associated genes across cancer lineages are MEK1, Notch1, and PDCD4. Each is linked with COLCA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both COLCA2-to-partner and partner-to-COLCA2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COLCA2→partner) and Y-score (partner→COLCA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.314	+1.700	.025	.042	3	2
UCEC	Notch1 →	+0.146	+2.009	.006	.017	3	2
COAD	PDCD4 →	-0.599	-3.000	.002	.035	3	2
COAD	Shc_pY317 →	-0.211	-3.313	.007	.010	3	2
UCEC	ATM →	-0.491	-3.308	.004	.009	3	2
UCEC	Di-Ras3 →	-0.207	-3.247	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Exploration

COLCA2 survival (RNA) · tumor vs normal (RNA) · all COLCA2 data types