COL6A5

Across TCGA patient cohorts, COL6A5 mutation is significantly associated with the total protein of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL6A5-associated genes across cancer lineages are CD31, INPP4B, and JNK_pT183_Y185. Each is linked with COL6A5 in more than 3 cancer types. Because this analysis shows association rather than direction, both COL6A5-to-partner and partner-to-COL6A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD31 grouped by COL6A5-low versus COL6A5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL6A5→partner) and Y-score (partner→COL6A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD31 →	-0.128	-1.428	<.001	.001	3	4
BRCA	INPP4B →	-0.643	-1.700	.003	.046	3	3
UCEC	JNK_pT183_Y185 →	-0.152	-2.058	<.001	<.001	3	3
LUSC	p70-S6K →	+0.375	+3.331	.001	.005	3	3
UCEC	Shc_pY317 →	-0.168	-1.938	<.001	.001	3	3
UCEC	Di-Ras3 →	-0.198	-1.584	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

CD31 by COL6A5 expression — UCEC

Explore this box plot interactively →