COL6A2

Across TCGA patient cohorts, COL6A2 mutation is significantly associated with the RNA expression of many other genes, with 4,151 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL6A2-associated genes across cancer lineages are RHBDD3, TEDC2, and GAGE2E. Each is linked with COL6A2 in more than 4 cancer types. Because this analysis shows association rather than direction, both COL6A2-to-partner and partner-to-COL6A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RHBDD3 grouped by COL6A2-low versus COL6A2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL6A2→partner) and Y-score (partner→COL6A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RHBDD3 →	+0.428	+3.593	.005	.001	3	4
LUAD	TEDC2 →	+0.550	+2.505	.008	.009	3	4
LUAD	GAGE2E →	+0.069	+3.197	<.001	.001	3	4
SKCM	SEC13 →	+0.283	+2.623	.005	.005	3	4
UCEC	TK1 →	+0.435	+2.684	.001	<.001	3	4
UCEC	PGAM1 →	+0.516	+1.799	.001	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,151 associations by consensus.

RHBDD3 by COL6A2 expression — LUAD

Explore this box plot interactively →