COL6A2

Across TCGA pan-cancer cohorts, COL6A2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of COL6A2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where COL6A2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types COL6A2 is over-expressed in tumor, although a few such as BLCA and UCEC show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where COL6A2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COL6A2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+3.876	<.001	12	view →
KIRC	Female	III,IV	+2.012	<.001	11	view →
BLCA	Male	III,IV	−2.244	<.001	8	view →
UCEC	All	All	−2.219	<.001	6	view →
LUAD	Male	III,IV	+1.144	.012	3	view →
KICH	All	All	−0.860	.029	2	view →
PRAD	All	All	−0.685	<.001	2	view →
READ	Female	All	−1.464	.044	1	view →
CHOL	All	All	+1.304	.027	1	view →
LIHC	Female	All	+0.833	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

COL6A2–HNSC

Open the HNSC breakdown →