COL6A2

Across TCGA patient cohorts, COL6A2 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL6A2-associated genes across cancer lineages are Caspase-7-cleavedD198, Lck, and eIF4E. Each is linked with COL6A2 in more than 3 cancer types. Because this analysis shows association rather than direction, both COL6A2-to-partner and partner-to-COL6A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by COL6A2-low versus COL6A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL6A2→partner) and Y-score (partner→COL6A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.669	+1.373	<.001	.008	3	4
STAD	Lck →	+0.305	+2.828	.007	.033	3	3
COAD	eIF4E →	+0.209	+2.528	<.001	.001	3	3
UCEC	ATM →	-0.497	-3.446	<.001	<.001	3	3
COAD	4E-BP1_pT70 →	+0.152	+2.511	<.001	.001	3	3
COAD	4E-BP1 →	+0.253	+2.115	.001	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

Caspase-7-cleavedD198 by COL6A2 expression — UCEC

Explore this box plot interactively →